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Dangers of Uric Acid



The debate over the role of uric acid in heart disease has been going on for more than 50 years, starting with a paper published in 1951 which found higher serum uric acid concentrations in patients with coronary heart disease.

New research shows that higher levels of uric acid are strongly associated with high blood pressure in blacks. The association between uric acid and hypertension is much stronger in blacks, a group that disproportionately suffers from kidney disease, stroke and other complications of hypertension.

Uric acid levels are influenced by dietary factors, such as high levels of protein, and by the breakdown of the body's cells. Most uric acid is eliminated in urine. However, if excess uric acid is being produced or if the kidneys cannot remove enough of it, levels build up in the blood.

Very high levels of uric acid cause gout, but recent animal and human studies suggest that modest elevations of uric acid are one cause of hypertension.

Pregnant women with hypertension who also have elevated blood uric acid levels may face an increased risk of complications that could be fatal for mother and baby. Women with both preeclampsia and elevated uric acid levels had a nearly seven-fold increased risk of premature delivery and delivered nearly four weeks earlier than preeclamptic women whose uric acid levels were normal.







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